| 1 | Rice over #15Marshall 20–0 · on the road · 2020-12-05 | 2020 | +24 | +44.0 | 7% | 15 |
| 2 | Maryland over Penn State 35–19 · on the road · 2020-11-07 | 2020 | +27.5 | +43.5 | 4% | — |
| 3 | Air Force over Navy 40–7 · at home · 2020-10-03 | 2020 | +6.5 | +39.5 | 34% | — |
| 4 | Pittsburgh over Virginia Tech 47–14 · at home · 2020-11-21 | 2020 | +6.5 | +39.5 | 34% | — |
| 5 | #20North Carolina over #9Miami 62–26 · on the road · 2020-12-12 | 2020 | +3 | +39.0 | 43% | 11 |
| 6 | #5Oklahoma over #8Florida 55–20 · neutral site · 2020-12-31 | 2020 | +3 | +38.0 | 43% | — |
| 7 | UTEP over UL Monroe 31–6 · on the road · 2020-09-26 | 2020 | +9.5 | +34.5 | 28% | — |
| 8 | Illinois over Nebraska 41–23 · on the road · 2020-11-21 | 2020 | +16.5 | +34.5 | 15% | — |
| 9 | Kentucky over #18Tennessee 34–7 · on the road · 2020-10-17 | 2020 | +6.5 | +33.5 | 34% | 12 |
| 10 | Coastal Carolina over Arkansas State 52–23 · at home · 2020-10-03 | 2020 | +3.5 | +32.5 | 41% | — |
| 11 | Troy over Arkansas State 38–10 · on the road · 2020-10-31 | 2020 | +3.5 | +31.5 | 41% | — |
| 12 | Kansas State over #3Oklahoma 38–35 · on the road · 2020-09-26 | 2020 | +27.5 | +30.5 | 4% | 27 |
| 13 | San José State over New Mexico 38–21 · on the road · 2020-10-31 | 2020 | +13.5 | +30.5 | 20% | — |
| 14 | Louisiana over Iowa State 31–14 · on the road · 2020-09-12 | 2020 | +13 | +30.0 | 21% | — |
| 15 | #9Cincinnati over #16SMU 42–13 · on the road · 2020-10-25 | 2020 | +1 | +30.0 | 48% | — |
| 16 | #23Ball State over #24San José State 34–13 · neutral site · 2020-12-31 | 2020 | +9 | +30.0 | 29% | — |
| 17 | Tulsa over #11UCF 34–26 · on the road · 2020-10-03 | 2020 | +20.8 | +28.8 | 10% | 19 |
| 18 | #2Ohio State over #1Clemson 49–28 · neutral site · 2021-01-02 | 2020 | +7 | +28.0 | 33% | 1 |
| 19 | UCLA over California 34–10 · at home · 2020-11-15 | 2020 | +3.5 | +27.5 | 41% | — |
| 20 | Wyoming over Hawai'i 31–7 · at home · 2020-10-31 | 2020 | +3 | +27.0 | 43% | — |
| 21 | East Carolina over SMU 52–38 · at home · 2020-11-28 | 2020 | +12 | +26.0 | 23% | — |
| 22 | LSU over #6Florida 37–34 · on the road · 2020-12-13 | 2020 | +23 | +26.0 | 8% | 24 |
| 23 | East Carolina over South Florida 44–24 · on the road · 2020-10-10 | 2020 | +5.5 | +25.5 | 37% | — |
| 24 | Georgia Tech over Duke 56–33 · at home · 2020-11-29 | 2020 | +2.5 | +25.5 | 44% | — |
| 25 | Louisville over Wake Forest 45–21 · at home · 2020-12-12 | 2020 | +1 | +25.0 | 48% | — |
| 26 | Syracuse over Georgia Tech 37–20 · at home · 2020-09-26 | 2020 | +7.5 | +24.5 | 32% | — |
| 27 | Mississippi State over #6LSU 44–34 · on the road · 2020-09-26 | 2020 | +14.5 | +24.5 | 18% | 24 |
| 28 | Michigan State over #13Michigan 27–24 · on the road · 2020-10-31 | 2020 | +21.5 | +24.5 | 9% | 17 |
| 29 | Eastern Michigan over Western Michigan 53–42 · on the road · 2020-12-05 | 2020 | +13.5 | +24.5 | 20% | — |
| 30 | New Mexico over Fresno State 49–39 · at home · 2020-12-13 | 2020 | +14.5 | +24.5 | 18% | — |
| 31 | Arkansas over #16Mississippi State 21–14 · on the road · 2020-10-03 | 2020 | +17 | +24.0 | 14% | 14 |
| 32 | NC State over Virginia 38–21 · on the road · 2020-10-10 | 2020 | +7 | +24.0 | 33% | — |
| 33 | Georgia Tech over Louisville 46–27 · at home · 2020-10-09 | 2020 | +4.8 | +23.8 | 38% | — |
| 34 | South Alabama over Southern Miss 32–21 · on the road · 2020-09-04 | 2020 | +12.5 | +23.5 | 22% | — |
| 35 | Boston College over Duke 26–6 · on the road · 2020-09-19 | 2020 | +3.5 | +23.5 | 41% | — |
| 36 | Fresno State over Colorado State 38–17 · at home · 2020-10-30 | 2020 | +2.5 | +23.5 | 44% | — |
| 37 | Southern Miss over Florida Atlantic 45–31 · at home · 2020-12-10 | 2020 | +9.5 | +23.5 | 28% | — |
| 38 | #19Iowa over #25Wisconsin 28–7 · at home · 2020-12-12 | 2020 | +2 | +23.0 | 45% | — |
| 39 | Michigan State over #11Northwestern 29–20 · at home · 2020-11-28 | 2020 | +13.5 | +22.5 | 20% | 19 |
| 40 | Ball State over #23Buffalo 38–28 · neutral site · 2020-12-19 | 2020 | +12.5 | +22.5 | 22% | 7 |
| 41 | Georgia State over East Carolina 49–29 · at home · 2020-10-03 | 2020 | +1.5 | +21.5 | 46% | — |
| 42 | San José State over San Diego State 28–17 · on the road · 2020-11-07 | 2020 | +10.5 | +21.5 | 26% | — |
| 43 | #10Indiana over #18Wisconsin 14–6 · on the road · 2020-12-05 | 2020 | +13.5 | +21.5 | 20% | — |
| 44 | Coastal Carolina over Kansas 38–23 · on the road · 2020-09-13 | 2020 | +6 | +21.0 | 35% | — |
| 45 | #13Indiana over #23Michigan 38–21 · at home · 2020-11-07 | 2020 | +4 | +21.0 | 40% | — |
| 46 | Hawai'i over Houston 28–14 · neutral site · 2020-12-24 | 2020 | +7 | +21.0 | 33% | — |
| 47 | Liberty over Western Kentucky 30–24 · on the road · 2020-09-19 | 2020 | +14.5 | +20.5 | 18% | — |
| 48 | North Texas over Middle Tennessee 52–35 · on the road · 2020-10-17 | 2020 | +3.5 | +20.5 | 41% | — |
| 49 | Rutgers over Michigan State 38–27 · on the road · 2020-10-24 | 2020 | +9.5 | +20.5 | 28% | — |
| 50 | Western Kentucky over Charlotte 37–19 · on the road · 2020-12-06 | 2020 | +2.5 | +20.5 | 44% | — |
| 51 | Mississippi State over Missouri 51–32 · at home · 2020-12-19 | 2020 | +1.5 | +20.5 | 46% | — |
| 52 | #25San José State over Boise State 34–20 · neutral site · 2020-12-19 | 2020 | +6.5 | +20.5 | 34% | — |
| 53 | #25Liberty over Virginia Tech 38–35 · on the road · 2020-11-07 | 2020 | +17 | +20.0 | 14% | — |
| 54 | Utah State over New Mexico 41–27 · at home · 2020-11-27 | 2020 | +6 | +20.0 | 35% | — |
| 55 | Maryland over Minnesota 45–44 · at home · 2020-10-30 | 2020 | +18.5 | +19.5 | 12% | — |
| 56 | Rutgers over Purdue 37–30 · on the road · 2020-11-28 | 2020 | +12.5 | +19.5 | 22% | — |
| 57 | Jacksonville State over Florida International 19–10 · on the road · 2020-10-23 | 2020 | +10.5 | +19.5 | 26% | — |
| 58 | #8Florida over #5Georgia 44–28 · neutral site · 2020-11-07 | 2020 | +3 | +19.0 | 43% | 3 |
| 59 | San José State over Air Force 17–6 · at home · 2020-10-25 | 2020 | +7.5 | +18.5 | 32% | — |
| 60 | Arkansas State over Kansas State 35–31 · on the road · 2020-09-12 | 2020 | +14.5 | +18.5 | 18% | — |
