| 1 | Hawai'i over Nevada 54–3 · on the road · 2019-09-29 | 2019 | +2 | +53.0 | 45% | — |
| 2 | Syracuse over Duke 49–6 · on the road · 2019-11-16 | 2019 | +9 | +52.0 | 29% | — |
| 3 | Kansas over Boston College 48–24 · on the road · 2019-09-13 | 2019 | +20.2 | +44.2 | 10% | — |
| 4 | Bowling Green over Toledo 20–7 · at home · 2019-10-12 | 2019 | +27 | +40.0 | 5% | — |
| 5 | UNLV over Vanderbilt 34–10 · on the road · 2019-10-12 | 2019 | +15.5 | +39.5 | 17% | — |
| 6 | Central Michigan over Northern Illinois 48–10 · at home · 2019-11-02 | 2019 | +1.5 | +39.5 | 46% | — |
| 7 | Duke over Virginia Tech 45–10 · on the road · 2019-09-27 | 2019 | +2.5 | +37.5 | 44% | — |
| 8 | #10Texas over #14Utah 38–10 · neutral site · 2020-01-01 | 2019 | +7 | +35.0 | 33% | — |
| 9 | Middle Tennessee over Florida International 50–17 · at home · 2019-10-26 | 2019 | +1 | +34.0 | 48% | — |
| 10 | Boston College over Syracuse 58–27 · on the road · 2019-11-02 | 2019 | +3 | +34.0 | 43% | — |
| 11 | Georgia State over Tennessee 38–30 · on the road · 2019-08-31 | 2019 | +24.5 | +32.5 | 6% | — |
| 12 | Southern Illinois over Massachusetts 45–20 · on the road · 2019-09-07 | 2019 | +6.5 | +31.5 | 34% | — |
| 13 | Kentucky over Missouri 29–7 · at home · 2019-10-26 | 2019 | +9.5 | +31.5 | 28% | — |
| 14 | Eastern Michigan over Northern Illinois 45–17 · on the road · 2019-11-20 | 2019 | +3.5 | +31.5 | 41% | — |
| 15 | Illinois over #6Wisconsin 24–23 · at home · 2019-10-19 | 2019 | +30.2 | +31.2 | 3% | 24 |
| 16 | BYU over Utah State 42–14 · on the road · 2019-11-03 | 2019 | +3 | +31.0 | 43% | — |
| 17 | Florida Atlantic over SMU 52–28 · at home · 2019-12-21 | 2019 | +7 | +31.0 | 33% | — |
| 18 | Kansas State over #5Oklahoma 48–41 · at home · 2019-10-26 | 2019 | +23.5 | +30.5 | 7% | 25 |
| 19 | Purdue over Maryland 40–14 · at home · 2019-10-12 | 2019 | +4.2 | +30.2 | 40% | — |
| 20 | Central Michigan over Eastern Michigan 42–16 · at home · 2019-10-05 | 2019 | +4 | +30.0 | 40% | — |
| 21 | Buffalo over Temple 38–22 · at home · 2019-09-21 | 2019 | +13.8 | +29.8 | 20% | — |
| 22 | Houston over North Texas 46–25 · on the road · 2019-09-29 | 2019 | +8 | +29.0 | 31% | — |
| 23 | Navy over Tulsa 45–17 · on the road · 2019-10-12 | 2019 | +1 | +29.0 | 48% | — |
| 24 | The Citadel over Georgia Tech 27–24 · on the road · 2019-09-14 | 2019 | +25.5 | +28.5 | 6% | — |
| 25 | #13Oregon over #5Utah 37–15 · neutral site · 2019-12-07 | 2019 | +6.5 | +28.5 | 34% | 8 |
| 26 | Vanderbilt over #22Missouri 21–14 · at home · 2019-10-19 | 2019 | +21 | +28.0 | 9% | 8 |
| 27 | Illinois over Purdue 24–6 · on the road · 2019-10-26 | 2019 | +9.5 | +27.5 | 28% | — |
| 28 | Western Kentucky over Arkansas 45–19 · on the road · 2019-11-09 | 2019 | +1 | +27.0 | 48% | — |
| 29 | Florida International over Miami 30–24 · at home · 2019-11-24 | 2019 | +21 | +27.0 | 9% | — |
| 30 | San José State over Arkansas 31–24 · on the road · 2019-09-21 | 2019 | +19.8 | +26.8 | 11% | — |
| 31 | #20Iowa over USC 49–24 · neutral site · 2019-12-28 | 2019 | +1 | +26.0 | 48% | — |
| 32 | Georgia Tech over Miami 28–21 · on the road · 2019-10-19 | 2019 | +18.5 | +25.5 | 12% | — |
| 33 | Boston College over NC State 45–24 · at home · 2019-10-19 | 2019 | +4 | +25.0 | 40% | — |
| 34 | Northwestern over Illinois 29–10 · on the road · 2019-11-30 | 2019 | +6 | +25.0 | 35% | — |
| 35 | Tennessee over South Carolina 41–21 · at home · 2019-10-26 | 2019 | +4.2 | +24.2 | 40% | — |
| 36 | West Virginia over NC State 44–27 · at home · 2019-09-14 | 2019 | +7 | +24.0 | 33% | — |
| 37 | #18Baylor over Oklahoma State 45–27 · on the road · 2019-10-19 | 2019 | +6 | +24.0 | 35% | — |
| 38 | Liberty over Buffalo 35–17 · at home · 2019-09-14 | 2019 | +5.8 | +23.8 | 36% | — |
| 39 | South Carolina over #3Georgia 20–17 · on the road · 2019-10-12 | 2019 | +20.8 | +23.8 | 10% | 27 |
| 40 | Colorado State over Fresno State 41–31 · on the road · 2019-10-26 | 2019 | +13.8 | +23.8 | 20% | — |
| 41 | Louisiana over Ohio 45–25 · on the road · 2019-09-21 | 2019 | +3 | +23.0 | 43% | — |
| 42 | Troy over Georgia Southern 49–28 · at home · 2019-11-09 | 2019 | +2 | +23.0 | 45% | — |
| 43 | Wyoming over Missouri 37–31 · at home · 2019-08-31 | 2019 | +16.8 | +22.8 | 15% | — |
| 44 | Stanford over #15Washington 23–13 · at home · 2019-10-06 | 2019 | +12.8 | +22.8 | 21% | 15 |
| 45 | UCLA over #19Washington State 67–63 · on the road · 2019-09-22 | 2019 | +18.5 | +22.5 | 12% | 11 |
| 46 | Oregon State over Arizona 56–38 · on the road · 2019-11-02 | 2019 | +4.5 | +22.5 | 39% | — |
| 47 | UCLA over Stanford 34–16 · on the road · 2019-10-18 | 2019 | +4.2 | +22.2 | 40% | — |
| 48 | Oregon State over UCLA 48–31 · on the road · 2019-10-06 | 2019 | +4.5 | +21.5 | 39% | — |
| 49 | Virginia Tech over #22Wake Forest 36–17 · at home · 2019-11-09 | 2019 | +2.5 | +21.5 | 44% | 8 |
| 50 | California over Washington State 33–20 · at home · 2019-11-10 | 2019 | +8.5 | +21.5 | 30% | — |
| 51 | Western Kentucky over Southern Miss 28–10 · on the road · 2019-11-23 | 2019 | +3.5 | +21.5 | 41% | — |
| 52 | Virginia Tech over Miami 42–35 · on the road · 2019-10-05 | 2019 | +14 | +21.0 | 19% | — |
| 53 | Nevada over #24San Diego State 17–13 · on the road · 2019-11-10 | 2019 | +17 | +21.0 | 14% | 6 |
| 54 | Louisiana Tech over Miami 14–0 · neutral site · 2019-12-26 | 2019 | +7 | +21.0 | 33% | — |
| 55 | Georgia State over Arkansas State 52–38 · at home · 2019-10-05 | 2019 | +6.5 | +20.5 | 34% | — |
| 56 | Miami over Florida State 27–10 · on the road · 2019-11-02 | 2019 | +3 | +20.0 | 43% | — |
| 57 | Colorado over Washington 20–14 · at home · 2019-11-24 | 2019 | +14 | +20.0 | 19% | — |
| 58 | Nevada over Fresno State 35–28 · on the road · 2019-11-24 | 2019 | +13 | +20.0 | 21% | — |
| 59 | Tulsa over UCF 34–31 · at home · 2019-11-09 | 2019 | +16.5 | +19.5 | 15% | — |
| 60 | Texas Tech over #21Oklahoma State 45–35 · at home · 2019-10-05 | 2019 | +9.5 | +19.5 | 28% | 9 |
