| 1 | New Mexico State over Liberty 49–14 · on the road · 2022-11-26 | 2022 | +24 | +59.0 | 7% | — |
| 2 | Charlotte over Rice 56–23 · on the road · 2022-10-29 | 2022 | +15 | +48.0 | 17% | — |
| 3 | South Carolina over #5Tennessee 63–38 · at home · 2022-11-20 | 2022 | +22.5 | +47.5 | 8% | 25 |
| 4 | Houston over East Carolina 42–3 · on the road · 2022-11-19 | 2022 | +6 | +45.0 | 35% | — |
| 5 | Akron over Northern Illinois 44–12 · on the road · 2022-11-26 | 2022 | +9.5 | +41.5 | 28% | — |
| 6 | Middle Tennessee over #25Miami 45–31 · on the road · 2022-09-24 | 2022 | +25.5 | +39.5 | 6% | 5 |
| 7 | Old Dominion over Coastal Carolina 49–21 · on the road · 2022-10-15 | 2022 | +11.5 | +39.5 | 24% | — |
| 8 | North Texas over Western Kentucky 40–13 · on the road · 2022-10-29 | 2022 | +10 | +37.0 | 27% | — |
| 9 | Navy over Tulsa 53–21 · at home · 2022-10-08 | 2022 | +4.5 | +36.5 | 39% | — |
| 10 | TCU over #18Oklahoma 55–24 · at home · 2022-10-01 | 2022 | +5 | +36.0 | 38% | 12 |
| 11 | Weber State over Utah State 35–7 · on the road · 2022-09-10 | 2022 | +6.5 | +34.5 | 34% | — |
| 12 | Duke over Miami 45–21 · on the road · 2022-10-22 | 2022 | +10 | +34.0 | 27% | — |
| 13 | Liberty over BYU 41–14 · at home · 2022-10-22 | 2022 | +7 | +34.0 | 33% | — |
| 14 | UTEP over Boise State 27–10 · at home · 2022-09-24 | 2022 | +16.5 | +33.5 | 15% | — |
| 15 | Middle Tennessee over Florida Atlantic 49–21 · at home · 2022-11-19 | 2022 | +5.5 | +33.5 | 37% | — |
| 16 | Florida International over Charlotte 34–15 · on the road · 2022-10-22 | 2022 | +14 | +33.0 | 19% | — |
| 17 | Northern Illinois over Eastern Michigan 39–10 · on the road · 2022-10-15 | 2022 | +3.5 | +32.5 | 41% | — |
| 18 | Texas State over App State 36–24 · at home · 2022-10-08 | 2022 | +19.5 | +31.5 | 11% | — |
| 19 | #3Michigan over #2Ohio State 45–23 · on the road · 2022-11-26 | 2022 | +9 | +31.0 | 29% | 1 |
| 20 | Illinois over Wisconsin 34–10 · on the road · 2022-10-01 | 2022 | +6.5 | +30.5 | 34% | — |
| 21 | #23Kansas State over Baylor 31–3 · on the road · 2022-11-13 | 2022 | +2.5 | +30.5 | 44% | — |
| 22 | Syracuse over Louisville 31–7 · at home · 2022-09-04 | 2022 | +6 | +30.0 | 35% | — |
| 23 | Florida International over New Mexico State 21–7 · on the road · 2022-10-02 | 2022 | +16 | +30.0 | 16% | — |
| 24 | Louisville over #10Wake Forest 48–21 · at home · 2022-10-29 | 2022 | +3 | +30.0 | 43% | 20 |
| 25 | Georgia State over Southern Miss 42–14 · on the road · 2022-11-05 | 2022 | +2 | +30.0 | 45% | — |
| 26 | Eastern Michigan over Arizona State 30–21 · on the road · 2022-09-18 | 2022 | +20.5 | +29.5 | 10% | — |
| 27 | Baylor over Texas Tech 45–17 · on the road · 2022-10-29 | 2022 | +1.5 | +29.5 | 46% | — |
| 28 | Temple over South Florida 54–28 · at home · 2022-11-05 | 2022 | +3.5 | +29.5 | 41% | — |
| 29 | Middle Tennessee over Colorado State 34–19 · on the road · 2022-09-10 | 2022 | +13.5 | +28.5 | 20% | — |
| 30 | UConn over Fresno State 19–14 · at home · 2022-10-01 | 2022 | +23 | +28.0 | 8% | — |
| 31 | Kansas over West Virginia 55–42 · on the road · 2022-09-10 | 2022 | +14 | +27.0 | 19% | — |
| 32 | Georgia Southern over Nebraska 45–42 · on the road · 2022-09-10 | 2022 | +23.5 | +26.5 | 7% | — |
| 33 | Kansas over Houston 48–30 · on the road · 2022-09-17 | 2022 | +8.5 | +26.5 | 30% | — |
| 34 | Georgia Tech over #24Pittsburgh 26–21 · on the road · 2022-10-02 | 2022 | +21.5 | +26.5 | 9% | 6 |
| 35 | Eastern Michigan over Western Michigan 45–23 · on the road · 2022-10-08 | 2022 | +4.5 | +26.5 | 39% | — |
| 36 | East Carolina over UCF 34–13 · at home · 2022-10-22 | 2022 | +5.5 | +26.5 | 37% | — |
| 37 | Nevada over Texas State 38–14 · at home · 2022-09-03 | 2022 | +2 | +26.0 | 45% | — |
| 38 | Arizona over #9UCLA 34–28 · on the road · 2022-11-13 | 2022 | +20 | +26.0 | 11% | 21 |
| 39 | #12Utah over #4USC 47–24 · neutral site · 2022-12-03 | 2022 | +3 | +26.0 | 43% | 8 |
| 40 | Marshall over #8Notre Dame 26–21 · on the road · 2022-09-10 | 2022 | +20.5 | +25.5 | 10% | 22 |
| 41 | Buffalo over Eastern Michigan 50–31 · on the road · 2022-09-24 | 2022 | +6.5 | +25.5 | 34% | — |
| 42 | Georgia State over Army 31–14 · on the road · 2022-10-01 | 2022 | +8.5 | +25.5 | 30% | — |
| 43 | Georgia Tech over #13North Carolina 21–17 · on the road · 2022-11-19 | 2022 | +21 | +25.0 | 9% | 17 |
| 44 | Texas A&M over #6LSU 38–23 · at home · 2022-11-27 | 2022 | +10 | +25.0 | 27% | 24 |
| 45 | Western Kentucky over South Alabama 44–23 · neutral site · 2022-12-22 | 2022 | +4 | +25.0 | 40% | — |
| 46 | Arizona over San Diego State 38–20 · on the road · 2022-09-03 | 2022 | +6.5 | +24.5 | 34% | — |
| 47 | Iowa over Purdue 24–3 · on the road · 2022-11-05 | 2022 | +3.5 | +24.5 | 41% | — |
| 48 | Notre Dame over #5Clemson 35–14 · at home · 2022-11-05 | 2022 | +3.5 | +24.5 | 41% | 25 |
| 49 | Michigan State over #14Illinois 23–15 · on the road · 2022-11-05 | 2022 | +16 | +24.0 | 16% | 16 |
| 50 | Rice over Louisiana 33–21 · at home · 2022-09-17 | 2022 | +11.5 | +23.5 | 24% | — |
| 51 | Marshall over James Madison 26–12 · on the road · 2022-10-22 | 2022 | +9.5 | +23.5 | 28% | — |
| 52 | Ohio over Buffalo 45–24 · at home · 2022-11-01 | 2022 | +2.5 | +23.5 | 44% | — |
| 53 | Miami over Georgia Tech 35–14 · on the road · 2022-11-12 | 2022 | +2 | +23.0 | 45% | — |
| 54 | Colorado over California 20–13 · at home · 2022-10-15 | 2022 | +15 | +22.0 | 17% | — |
| 55 | Bowling Green over Central Michigan 34–18 · on the road · 2022-10-22 | 2022 | +6 | +22.0 | 35% | — |
| 56 | William & Mary over Charlotte 41–24 · on the road · 2022-09-02 | 2022 | +4.5 | +21.5 | 39% | — |
| 57 | Bowling Green over Toledo 42–35 · on the road · 2022-11-16 | 2022 | +14.5 | +21.5 | 18% | — |
| 58 | Texas Tech over #21Ole Miss 42–25 · neutral site · 2022-12-29 | 2022 | +4.5 | +21.5 | 39% | 9 |
| 59 | App State over #6Texas A&M 17–14 · on the road · 2022-09-10 | 2022 | +18 | +21.0 | 13% | 24 |
| 60 | Ohio over Western Michigan 33–14 · on the road · 2022-10-15 | 2022 | +2 | +21.0 | 45% | — |
